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Human Body Study

Changelog

Notable, reader-facing changes to the Human Body Study knowledge base, newest first.

July 2026

  • Added Provocative Testing under HPG deviations — how GnRH and hCG stimulation tests probe the axis’s capacity to respond.

May 2026

  • Added Testosterone Therapy and Axis Recovery under HPG deviations — TRT vs abuse, recovery timeline, and the realistic worst cases of low-dose therapy.
  • Added the Male Development arc — a multi-chapter walk from a 46,XY embryo to adult maturity.
  • Added Fetal Sex Differentiation — the bipotential gonad, the SRY switch, and the Sertoli/Leydig handoff.
  • Added Minipuberty — the postnatal HPG flare and its lifelong Sertoli-cell consequences.
  • Added Childhood Quiescence — the prepubertal HPG axis at rest.
  • Added Adrenarche — the adrenal pre-puberty.
  • Added Gonadarche — sleep-gated nocturnal LH pulses reawaken the HPG axis at puberty.
  • Added the Tanner progression (G1–G5).
  • Added Post-pubertal Maturation — the long tail of facial hair, muscle, bone, and prefrontal-cortex changes.
  • Added Boyar’s nocturnal LH-pulse findings and the chronic-sleep-loss section to Gonadarche.
  • Added an Inhibin B page under HPG axis — the Sertoli FSH-feedback hormone.
  • Added an AMH page under HPG axis — fetal Müllerian regression and postnatal Sertoli reserve.
  • Added a follow-up tracking panel to Gonadarche — what to measure at each visit.
  • Added a visit-frequency guide to Gonadarche — 3–6 month intervals tuned to clinical concern.
  • Added a section on LH-preferential dissociation to the HPG deviations page.
  • Added an anterior body-view schematic to Anatomical Terminology, annotated with directional terms.
  • Added a lateral body-view schematic to Anatomical Terminology, annotated with directional terms.
  • Added a superior body-view schematic to Anatomical Terminology, annotated with directional terms.
  • Added an anatomical-planes diagram to Anatomical Terminology — sagittal, coronal, and transverse.
  • Added Gynecomastia under Male Development — the estrogen-vs-androgen ratio at the breast bud.
  • Added pathological-cause coverage to Gynecomastia — drugs, Klinefelter, hCG tumours, hyperprolactinemia, systemic disease.
  • Added Tunics and Lobules under Testes.
  • Added Seminiferous Tubules under Testes — Sertoli and spermatogenic cells.
  • Added Interstitial Tissue under Testes — Leydig cells.
  • Added Intratesticular Ducts under Testes — the route from the tubules to the epididymis.
  • Added Vasculature and Nerves under Testes — the cooling pampiniform plexus.
  • Added Scrotum and Cord under Testes.
  • Added a cut-away testis schematic doubling as a seminiferous-tubule cross-section.
  • Added Pulsatility to the HPG axis — the KNDy pulse generator.
  • Added Feedback Architecture to the HPG axis — testosterone, estradiol, and inhibin B loops with their diagnostic signatures.
  • Added Inputs to the Axis to the HPG axis — energy, stress, prolactin, thyroid, and opioids.
  • Added Across the Lifespan to the HPG axis — fetal life through senescence.
  • Added Deviations to the HPG axis — functional suppression, CHH and Kallmann, pituitary disease, primary gonadal failure, constitutional delay.
  • Added the Male Reproductive System subgroup with its overview schematic.
  • Added Testes under male reproductive.
  • Added the Duct System under male reproductive — epididymis, vas deferens, ejaculatory ducts.
  • Added Accessory Glands under male reproductive — seminal vesicles, prostate, bulbourethral.
  • Added the Penis page.
  • Added the Female Reproductive System subgroup with its overview schematic.
  • Added Ovaries.
  • Added Fallopian Tubes.
  • Added Uterus.
  • Added Cervix and Vagina.
  • Added Mammary Glands.
  • Added Meibomian Glands — eyelid sebaceous glands behind the tear-film lipid layer.
  • Added Glands of Zeis — lash-base sebaceous glands.
  • Added Montgomery’s Tubercles — areolar sebaceous glands.
  • Added Fordyce Spots — ectopic sebaceous glands on lips and genitals.
  • Added the Pilosebaceous Unit — the integrative unit of hair, sebaceous gland, and arrector pili muscle.
  • Enriched Sebaceous Glands with density figures, sapienic acid, the acid mantle, and vernix caseosa.
  • Added a clickable signal-flow schematic to each of the twelve hormonal-axis pages.
  • Added a hub-and-spoke overview map to the hormonal-axes index page.
  • Added the Tendons page — muscle-to-bone connective tissue, partner to ligaments.
  • Added a clickable schematic to each of the eleven organ-system overview pages.
  • Added a clickable cell schematic to the Cells overview — nine organelles labelled and linked.
  • Added a clickable tissue schematic to the Tissues overview — four tissue types in a generalized organ wall.
  • Added the Regulation root — homeostasis and cross-system integration.
  • Added Feedback Loops under Regulation.
  • Added Thermoregulation under Regulation.
  • Added Blood Glucose Regulation under Regulation.
  • Added Blood Pressure Regulation under Regulation.
  • Added Fluid and Electrolyte Balance under Regulation.
  • Added Acid-Base Balance under Regulation.
  • Added Blood Gas Regulation under Regulation.
  • Added Calcium Regulation under Regulation.
  • Added Energy Balance under Regulation.
  • Added Circadian Rhythm under Regulation.
  • Added Stress Response under Regulation.
  • Added organ-detail pages for the Cardiovascular system.
  • Added organ-detail pages for the Digestive system.
  • Added organ-detail pages for the Endocrine system.
  • Added organ-detail pages for the Lymphatic and Immune system.
  • Added organ-detail pages for the Reproductive system.
  • Added organ-detail pages for the Respiratory system.
  • Added organ-detail pages for the Urinary system.
  • Added the Prenatal Development stage pages.
  • Launched the Human Body Study knowledge base.
  • Added the Foundations root with its initial pages.
  • Added the Organ Systems root with the eleven systems.
  • Added the Lifespan root with its initial stage pages.